Curriculum Vitae of Dr. Jing Gong Professor in Bioinformatics College of Informatics, Huazhong Agricultural University 1 Shizishan Jie, Hongshan Qu, Wuhan 430070, China E-mail: gong.jing@mail.hzau.edu.cn / Tel.: |
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Research interest
Ø Big data mining and integrative analysis from high throughput data, including both DNA and RNA sequences, protein profiling, and epigenetic profiling, to decipher genetic effects on gene regulation in cancer biology.
Ø Molecular epidemiological and biochemical approaches to investigate the associations between genetic variants and susceptibility to common cancers.
Ø Non-coding RNAs related bioinformatics analysis and database construction.
Education & academic appointments
10/2018-present |
Professor in Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, China |
05/2018-09/2018 |
Associate professor, School of public health, Huazhong University of Science & Technology, Wuhan, China |
04/2016-04/2018 |
Post-doctoral Research Fellow, University of Texas Health Science Center at Houston Medical School, USA |
07/2013-03/2016 |
Post-doctoral Research Fellow/ Lecturer, School of public health, Huazhong University of Science & Technology, Wuhan, China |
09/2008-06/2013 |
Ph.D. in Bioinformatics, Huazhong University of Science & Technology, Wuhan, China |
09/2003-06/2008 |
Bachelor of medicine in Public Health, Huazhong University of Science & Technology, Wuhan, China |
Ongoing and finished third-party funding
2020.01-2023.12 |
National Natural Science Foundation of China (NSFC) grant: Systematically evaluate the effects of genetic variants on alternative polyadenylation in multiple cancer types and further functional investigation |
2018.10-2023.10 |
Huazhong Agricultural University Startup grant: “Bioinformatics” (1 million RMB Yuan for 5 years) |
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2014.01-2016.12 |
National Natural Science Foundation of China (NSFC) grant: “Identification of risk variant in regulatory risk for colorectal cancer in Chinese population” |
08/2014 |
Special Financial Grant from the China Postdoctoral Science Foundation: “Identification of risk variant in regulatory risk for liver cancer in Chinese population” |
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Publications
(* for corresponding author)
1. Yang, W., Yang, Y., Zhao, C., Yang, K., Wang, D., Yang, J., Niu, X.* and Gong, J*. (2019) Animal-ImputeDB: a comprehensive database with multiple animal reference panels for genotype imputation. Nucleic acids research.
2. Yang, Y., Zhang, Q., Miao, Y.R., Yang, J., Yang, W., Yu, F., Wang, D., Guo, A.Y.* and Gong, J.* (2019) SNP2APA: a database for evaluating effects of genetic variants on alternative polyadenylation in human cancers. Nucleic acids research.
3. Li, J., Xue, Y., Amin, M.T., Yang, Y., Yang, J., Zhang, W., Yang, W., Niu, X., Zhang, H.Y. and Gong, J.* (2019) ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types. Nucleic acids research.
4. Tian, J.B.#, Chang, J.#, Gong, J.#, Lou, J., Fu, M.P., Li, J.Y., Ke, J.T., Zhu, Y., Gong, Y.J., Yang, Y. et al. (2019) Systematic Functional Interrogation of Genes in GWAS Loci Identified ATF1 as a Key Driver in Colorectal Cancer Modulated by a Promoter-Enhancer Interaction. Am J Hum Genet, 105, 29-47.
5. Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X. and Han, L. (2018) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic Acids Res.
6. Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs6983267. Annals of oncology. 29(3), 632-639.
7. Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhu, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X. (2018) Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer, 93, 1-9.
8. Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981. (featured as Cover story)
9. Gong, J., Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research. 46, D971–D976.
10. Gong, J., Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84.
11. Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Gong, J*. (2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021.
12. Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451.
13. Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. and Gong, J.* (2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194.
14. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207.
15. Gong, J., Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186.
16. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. and Gong, J.* (2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e0138478.
17. Gong, J., Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029.
18. Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L., Gong, J.* and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480.
19. Gong, J., Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385.
20. Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306.
21. Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B., Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.
22. Liu, D.＃, Gong, J.#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146.
23. Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263.
